Genetic studies in complex disease
نویسندگان
چکیده
منابع مشابه
Genetic studies in Alzheimer's disease
Alzheimer's disease (AD), the most common cause of dementia in aged populations, is believed to be caused by both environmental factors and genetic variations. Extensive linkage and association studies have established that a broad range of loci are associated with AD, including both causative and susceptibility (risk factor) genes. So far, at least three genes, APP, PS1, and PS2, have been ide...
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Many of our most common diseases are complex disorders, run in families, but they lack the simple inheritance patterns characteristics of single gene disorders. Complex diseases have low heritability compared to single gene disorders. Understanding the genetic factors underlying common disorders is a difficult but critical task because each genetic and environmental factor can contribute toward...
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Attempting to classify patients into high or low risk for disease onset or outcomes is one of the cornerstones of epidemiology. For some (but by no means all) diseases, clinically usable risk prediction can be performed using classical risk factors such as body mass index, lipid levels, smoking status, family history and, under certain circumstances, genetics (e.g. BRCA1/2 in breast cancer). Th...
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In light of this, it is likely that GWAS hits found in intergenic regions far from known genes are true associations whose biology is not yet understood, rather than false positives. The human genome is incompletely annotated. Regions where GWAS associations have been found, but no known genes are located, could easily harbor unidentified new genes or regulatory elements. For instance, the auth...
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We have developed a robust microarray genotyping chip that will help advance studies in genetic epidemiology. In population-based genetic association studies of complex disease, there could be hidden genetic substructure in the study populations, resulting in false-positive associations. Such population stratification may confound efforts to identify true associations between genotype/haplotype...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2004
ISSN: 1538-7933,1538-7836
DOI: 10.1111/j.1538-7933.2004.0643a.x